Author(s): Zeynep Bayramoglu*, Betul Unal, Ozlenen Ozkan, Cumhur Ibrahim Bassorgun
Background: Currently, several new treatment strategies targeting specific signaling pathways and immunotherapy are being explored for malignant melanoma. We investigated the relationship between notch-1 gene expression by immunohistochemistry in patients with malignant melanoma.
Objective: We investigated the relationship between malignant melanoma and notch-1 in this study.
Methods: In our study, 10 patients with intradermal nevus and 27 patients with malignant melanoma were studied by immunohistochemistry with notch-1.
Results: We found notch-1 expression in 11 of our 27 patients. There was a significant correlation between sentinel lymph node metastasis and notch-1 expression (p<0,05). Our study has shown that the notch signaling pathway is associated with sentinel lymph node metastasis. As a result of our work, notch pathway is involved in malignant melanoma formation and lymph node metastasis. It should be kept in mind that the effect of the notch pathway on malignant melanoma may be beneficial in targeted treatment.
